منابع مشابه
Prostaglandin H synthase. Effects of peroxidase cosubstrates on cyclooxygenase velocity.
Many cosubstrates for the peroxidase activity of prostaglandin H synthase-1 (PGHS-1) have been reported to produce a large (2-7-fold) increase in the cyclooxygenase velocity in addition to a substantial increase in the number of cyclooxygenase catalytic turnovers. The large stimulation of cyclooxygenase velocity has become an important criterion for evaluation of putative PGHS reaction mechanis...
متن کاملProteolysis in the lung.
Pulmonary emphysema is a major component of the morbidity and mortality of chronic obstructive pulmonary disease (COPD), a condition that has become the fourth leading cause of death in the USA, and is becoming epidemic worldwide. Emphysema is defined as enlargement of peripheral airspaces of the lung including respiratory bronchioles, alveolar ducts and alveoli, accompanied by destruction of t...
متن کاملProteolysis in colorectal cancer.
BACKGROUND The process of metastasis is complex, involving many interrelated stages, including proteolysis. Proteolysis occurs in both normal and pathological processes and involves the breakdown of the extracellular matrix and/or basement membrane by proteolytic enzymes. Normally, proteolysis is tightly controlled by specific endogenous proteinase inhibitors. However, in certain disease proces...
متن کاملUbiquitin-dependent proteolysis in neurons.
Various studies identified the ubiquitin-proteasome system as the prime suspect in causing neurodegenerative diseases. The present review summarizes our current knowledge about the expression, regulation, and functions of this major protein degradation pathway in the brain, with particular reference to the pathogenesis of associated neurological diseases.
متن کاملProteolysis in human breast cancer.
BACKGROUND The process of proteolysis is important at several stages of the metastatic cascade. A balance between the expression of the genes encoding endogenous proteinases and inhibitors exists and when the production of proteinases exceeds that of inhibitors proteolysis occurs. AIMS To determine whether differences in the profile and activity of proteinases and inhibitors exist within brea...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1939
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)73624-7